irritate in WordNet English dictionary

1. cause annoyance in; disturb, especially by minor irritations
   "Mosquitoes buzzing in my ear really bothers me"; "It irritates me that she never closes the door after she leaves"
   annoy  rag  get to  bother  get at  irritate  rile  nark  nettle  gravel  vex  chafe  devil 
   
2. excite to an abnormal condition, or chafe or inflame
   "Aspirin irritates my stomach"
   irritate 
   
3. excite to some characteristic action or condition, such as motion, contraction, or nervous impulse, by the application of a stimulus
   "irritate the glands of a leaf"
   irritate