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English word:    

malady

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malady in WordNet English dictionary

noun
  1. impairment of normal physiological function affecting part or all of an organism
    illness  unwellness  malady  sickness 
  2. any unwholesome or desperate condition
    "what maladies afflict our nation?"
    malady 
WordNet Lexical Database v3.0, © 2006 Princeton University